A commercial territory design problem with compactness maximization criterion subject to territory balancing and connectivity is addressed.Four new heuristics based on Greedy Randomized Adaptive Search Procedures within a location-allocation scheme for this NP-hard combinatorial optimization problem are proposed.The first three (named GRLH1, GRLH2,
Alpha-dystroglycan requires a rare O-mannose glycan modification to form its binding epitope for extracellular matrix proteins such as laminin.This functional glycan is disrupted in a cohort of muscular dystrophies, the secondary dystroglycanopathies, and is abnormal in some metastatic cancers.The most commonly used reagent for detection of alpha-d
The Pilgrimage Church of St.John of Nepomuk is a UNESCO World Heritage Site.This article presents the restoration work on a critically damaged parterre floor, involving the identification of the materials of the original tiles, the manufacture of boys romper replicas, and the design of the final tile layout.The original floor layout consisting of t